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Suitable scientific studies performed to date have not shown geriatric-unique problems that could Restrict the usefulness of sildenafil inside the aged.

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Nonetheless, pharmacokinetic interactions involving grapefruit juice are sometimes issue into a superior diploma of interpatient variability and should be considerable from the occasional susceptible client.

Sickle-cell anemia (blood ailment)—Sildenafil needs to be applied with warning in these clients as problems with prolonged erection in the penis may possibly come about.

Caution should really ultimately be exercised when sildenafil is administered to nursing Gals as It isn't recognised if sildenafil or its metabolites are excreted in human breast milk .

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In solitary-dose volunteer reports of doses as many as 800 mg, adverse reactions had been comparable to These viewed at reduced doses, nevertheless the incidence rates and severities ended up amplified .

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MANAGEMENT: It may be a good idea to stay away from administration of sildenafil with grapefruit juice to stop likely toxicity and hold off in onset of action.

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